What Are the Different Schedules of Drugs


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In criminal prosecutions, one often hears various drugs referred to by different schedules. But what are the schedules, which drugs are on them, and what do they mean?

Schedule I controlled substances

Schedule I substances are those that have the following characteristics: (a) the drug or other substance has a high potential for abuse, (b) the drug or other substance has no currently accepted medical use in treatment in the United States, (c) there is a lack of accepted safety for use of the drug or other substance under medical supervision. No prescriptions may be written for Schedule I substances

Drugs in this schedule include:

-αMT (alpha-methyltryptamine), an anti-depressant from the tryptamine family (brand name Indopan).
-BZP (benzylpiperazine), a synthetic stimulant once sold as a designer drug.
-Cathinone, an amphetamine-like stimulant found in the shrub Catha edulis (khat).
-DMT (dimethyltryptamine), a naturally-occurring psychedelic drug that is widespread throughout the plant kingdom.
-GHB, a general anesthetic, it was placed in Schedule I in March 2000 after widespread recreational use. This drug is also listed in Schedule III for limited uses, under the trademark Xyrem.
-Heroin (diacetylmorphine).
-LSD (lysergic acid diethylamide).
-Marijuana including the cannabis plant and its cannabinoids.
-MDMA ("ecstasy").
-Mescaline, a naturally-occurring psychedelic drug and the main psychoactive constituent of peyote (Lophophora williamsii), San Pedro cactus (Echinopsis pachanoi), and Peruvian torch cactus (Echinopsis peruviana).
-Methaqualone (Quaalude, Sopor, Mandrax), a sedative that was previously used for similar purposes as barbiturates.
-Peyote (Lophophora williamsii), a cactus growing in nature primarily in northeastern Mexico; one of the few plants specifically scheduled.
-Psilocybin and psilocin, naturally-occurring psychedelic drugs and the main psychoactive constituents of psilocybin mushrooms.
-Controlled substance analogs intended for human consumption (as defined by the Federal Analog Act)

Schedule II controlled substances

Schedule II substances are those that have the following characteristics: (a) the drug or other substances have a high potential for abuse, (b) the drug or other substances have currently accepted medical use in treatment in the United States, or currently accepted medical use with severe restrictions (c) abuse of the drug or other substances may lead to severe psychological or physical dependence.

Except when dispensed directly by a practitioner, other than a pharmacist, to an ultimate user, no controlled substance in Schedule II, which is a prescription drug as determined under the Federal Food, Drug, and Cosmetic Act may be dispensed without the written prescription of a practitioner, No prescription for a controlled substance in schedule II may be refilled.

Drugs in this schedule include:

-Cocaine (used as a topical anesthetic).
-Methylphenidate (Ritalin) and dexmethylphenidate (Focalin), used in treatment of attention deficit disorder.
-Amphetamines.
-Mixed amphetamine salts (Adderall).
-Opium and opium tincture (laudanum), which is used as a potent antidiarrheal.
-Methadone, used in treatment of heroin addiction as well as for treatment of extreme chronic pain.
-Oxycodone, semi-synthetic opioid; active ingredient in Percocet, OxyContin, and Percodan.
-Oxymorphone, semi-synthetic opioid; active ingredient in Opana.
-Fentanyl and most other strong pure opioid agonists, i.e. levorphanol, opium.
-Morphine.
-Lisdexamfetamine (Vyvanse).
-Dextroamphetamine (Dexedrine).
-Dextromethamphetamine (Desoxyn).
-Hydromorphone (semi-sythetic opioid; active ingredient in Dilaudid, Palladone).
-Pure codeine and any drug for non-parenteral administration containing the equivalent of more than 90 mg of codeine per dosage unit.
-Pure hydrocodone and any drug for non-parenteral administration containing no other active ingredients or more than 15 mg per dosage unit.
-Secobarbital (Seconal).
-Pethidine (USAN: Meperidine; Demerol).
-Phencyclidine (PCP).
-Short-acting barbiturates, such as pentobarbital, Nembutal.
-Nabilone (Cesamet).
-Tapentadol (Nucynta).

Schedule III controlled substances

Schedule III substances are those that have the following characteristics: (a) the drug or other substance has a potential for abuse less than the drugs or other substances in schedules I and II, (b) the drug or other substance has a currently accepted medical use in treatment in the United States, (c) abuse of the drug or other substance may lead to moderate or low physical dependence or high psychological dependence.

Except when dispensed directly by a practitioner, other than a pharmacist, to an ultimate user, no controlled substance in schedule III or IV, which is a prescription drug as determined under the Federal Food, Drug, and Cosmetic Act, may be dispensed without a written or oral prescription. Such prescriptions may not be filled or refilled more than six months after the date thereof or be refilled more than five times after the date of the prescription unless renewed by the practitioner. Control of wholesale distribution is somewhat less stringent than Schedule II drugs.

Drugs in this schedule include:

-Anabolic steroids (including prohormones such as androstenedione).
-Intermediate-acting barbiturates, such as talbutal or butalbital.
-Buprenorphine (semi-synthetic opioid; active in Suboxone, Subutex).
-Dihydrocodeine when compounded with other substances, to a certain dosage and concentration.
-Ketamine, a drug originally developed as a safer, shorter-acting replacement for PCP (mainly for use as a human anesthetic) but has since become popular as a veterinary and pediatric anesthetic.
-Xyrem, a preparation of GHB used to treat narcolepsy.
-Hydrocodone / codeine, when compounded with an NSAID (e.g. Vicoprofen, when compounded with ibuprofen) or with acetaminophen (paracetamol) (e.g. Vicodin / Tylenol 3).
-Marinol, synthetically prepared tetrahydrocannabinol (officially referred to by its INN, dronabinol) used to treat nausea and vomiting caused by chemotherapy, as well as appetite loss caused by AIDS.
-Paregoric, an antidiarrheal and anti-tussive, which contains opium combined with camphor (which makes it less addiction-prone than laudanum, which is in Schedule II).
-Phendimetrazine Tartrate, a stimulant synthesized for use as an anorexiant.
-Benzphetamine HCl (Didrex), a stimulant designed for use as an anorexiant.
-Fast-Acting barbiturates such as secobarbital (Seconal) and pentobarbital (Nembutal), when combined with one or more additional active ingredient(s) not in Schedule II (e.g., Carbrital).
-Ergine (lysergic acid amide), listed as a sedative but considered by some to be psychedelic.

Schedule IV controlled substances

Schedule IV substances are those that have the following characteristics: (a) the drug or other substance has a low potential for abuse relative to the drugs or other substances in schedule III, (b) the drug or other substance has a currently accepted medical use in treatment in the United States, and (c) abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in schedule III.

Control measures are similar to Schedule III. Prescriptions for Schedule IV drugs may be refilled up to five times within a six-month period.

Drugs in this schedule include:
-Benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clonazepam (Klonopin), diazepam (Valium).
-Temazepam (Restoril).
-Flunitrazepam (Rohypnol).
-The benzodiazepine-like Z-drugs: zolpidem (Ambien), zopiclone (Imovane), eszopiclone (Lunesta), and zaleplon (Sonata) (zopiclone is not commercially available in the U.S.).
-Chloral hydrate, a sedative-hypnotic;
-Long-acting barbiturates such as phenobarbital;
-Some partial agonist opioid analgesics, such as pentazocine (Talwin);
-Modafinil (sold in the U.S. as Provigil) as well as its (R)-enantiomer armodafinil (sold in the U.S. as Nuvigil).
-Difenoxin, an antidiarrheal drug.
-Tramadol (Ultram).
-Carisoprodol (Soma).

Schedule V controlled substances

Schedule V substances are those that have the following characteristics: (a) the drug or other substance has a low potential for abuse relative to the drugs or other substances in schedule IV, (b) the drug or other substance has a currently accepted medical use in treatment in the United States, and (c) abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in schedule IV.

No controlled substance in schedule V which is a drug may be distributed or dispensed other than for a medical purpose.

Drugs in this schedule include:

-Cough suppressants containing small amounts of codeine (e.g., promethazine+codeine);
-Preparations containing small amounts of opium or diphenoxylate (used to treat diarrhea);
-Some anticonvulsants, such as pregabalin (Lyrica), lacosamide (Vimpat) and retigabine (Potiga/Trobalt);
-Pyrovalerone (used to treat chronic fatigue and as an appetite suppressant for weight loss);
-Some centrally-acting antidiarrheals, such as diphenoxylate (Lomotil) when mixed with atropine (to make it unpleasant for people to grind up, cook, and inject).

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