In 2000, a train owned and operated by Union Pacific Railroad struck and killed Charles Conway, a member of a paving crew working on a roadway near Sky Harbor Airport in Phoenix, Arizona. Conway was operating an asphalt roller and did not hear the train.

Arizona's drunk-driving accident numbers are extremely high despite preventative measures and strict laws.

On May 23, 2010 hundreds of motorcyclists rode from Toby Keith's "I Love This Bar and Grill" in Mesa to Greasewood Flats in North Scottsdale to bring awareness to motorcycle safety in Arizona. The symbolic event, organized by the Phoenix Motorcycle Riding Group and the Phoenix Motorcycle Kruzers, came about as part of a nationwide effort to promote Motorcycle Awareness Month. Similar rides have been organized in Houston, Austin and San Antonio, Texas.