FDA has issued a warning that there is an increased risk of bladder cancer in certain patients taking Actos. The risk seems to be considerably higher for those that take the drug at higher cumulative doses and for longer periods of time. Although Actos continues to remain on the shelves of drug stores in the United States, the drug is under a long-term observational study by the FDA. France and Germany have suspended the drug, due to the mounting concerns for its citizens.

Actos is a diabetes drug and is used to treat Type II diabetes. Recently, the FDA began a research study on the safety of Actos. This research study was created as a result of the concern of many people over the ability of Actos to increase the risk of bladder cancer.